Neurotoxicity of domoic acid in cerebellar granule neurons in a genetic model of glutathione deficiency
G Giordano, CC White, LA McConnachie… - Molecular …, 2006 - ASPET
… This study investigated the role of cellular antioxidant defense mechanisms in modulating
the neurotoxicity of domoic acid (DomA), by using cerebellar granule neurons (CGNs) from …
the neurotoxicity of domoic acid (DomA), by using cerebellar granule neurons (CGNs) from …
Low-level domoic acid protects mouse cerebellar granule neurons from acute neurotoxicity: Role of glutathione
G Giordano, TJ Kavanagh, EM Faustman… - toxicological …, 2013 - academic.oup.com
… a model for a relatively common polymorphism (C588T) in the 5′-flanking region of the GCLM
gene, … individuals with genetic polymorphisms of GCLM may be particularly at risk for the …
gene, … individuals with genetic polymorphisms of GCLM may be particularly at risk for the …
Glutathione Levels Modulate Domoic Acid–Induced Apoptosis in Mouse Cerebellar Granule Cells
G Giordano, CC White, I Mohar… - Toxicological …, 2007 - academic.oup.com
… of mouse cerebellar granule neurons (CGNs) to domoic acid … that neuronal degeneration
observed during domoic acid–… Similarly, domoic acid neurotoxicity in mixed hippocampal cell …
observed during domoic acid–… Similarly, domoic acid neurotoxicity in mixed hippocampal cell …
Apoptosis induced by domoic acid in mouse cerebellar granule neurons involves activation of p38 and JNK MAP kinases
G Giordano, HM Klintworth, TJ Kavanagh… - Neurochemistry …, 2008 - Elsevier
… neurotoxicity and (3) glutathione (GSH) levels modulate the necrotic and apoptotic effects of
DomA. In particular, neurotoxicity of … The results provide another model indicating a role for …
DomA. In particular, neurotoxicity of … The results provide another model indicating a role for …
Domoic acid as a developmental neurotoxin
LG Costa, G Giordano, EM Faustman - Neurotoxicology, 2010 - Elsevier
… of studies have investigated the neurotoxic effects of DomA in … concentration of DomA to
upregulate glutathione (GSH) synthesis (… For example, depletion of GSH by chemical or genetic …
upregulate glutathione (GSH) synthesis (… For example, depletion of GSH by chemical or genetic …
[HTML][HTML] Domoic acid-induced neurotoxicity is mainly mediated by the AMPA/KA receptor: comparison between immature and mature primary cultures of neurons and …
HT Hogberg, AK Bal-Price - Journal of toxicology, 2011 - hindawi.com
… genes identified as specific markers for glial and neuronal cells … neuronal-glia cultures of
primary rat cerebellar granule cells (… In our mixed neuronal-glial cell culture model, the mRNA …
primary rat cerebellar granule cells (… In our mixed neuronal-glial cell culture model, the mRNA …
[HTML][HTML] Domoic acid toxicologic pathology: a review
OM Pulido - Marine Drugs, 2008 - mdpi.com
… in DOM toxicity using an in vitro model of neonatal rat microglia [… seizure or any clinical signs
of neurotoxicity, it did induce … Their cloning has revealed the molecular diversity of the gene …
of neurotoxicity, it did induce … Their cloning has revealed the molecular diversity of the gene …
Domoic acid as a neurotoxin
A Pérez-Gómez, RA Tasker - Handbook of neurotoxicity, 2023 - Springer
… Neurotoxicity of domoic acid in cerebellar granule neurons in a genetic model of glutathione
deficiency. Molecular … Glutathione levels modulate domoic acid induced apoptosis in mouse …
deficiency. Molecular … Glutathione levels modulate domoic acid induced apoptosis in mouse …
Long-term neurotoxic effects of domoic acid on primary dopaminergic neurons
… leads to striatal dopaminergic deficiency, and formation of … apoptotic cell death in cerebellar
granule neurons (CGNs) and … PD cellular model, to show the long-term neurotoxic effects of …
granule neurons (CGNs) and … PD cellular model, to show the long-term neurotoxic effects of …
From the Cover: Selective Enhancement of Domoic Acid Toxicity in Primary Cultures of Cerebellar Granule Cells by Lowering Extracellular Na+ Concentration
A Pérez-Gómez, D Cabrera-García… - Toxicological …, 2018 - academic.oup.com
… used primary cultures of cerebellar neurons to test whether … cultures to be a very convenient
experimental model to investigate … Domoic acid neurotoxicity was completely prevented by …
experimental model to investigate … Domoic acid neurotoxicity was completely prevented by …